Across TCGA cell cohorts, RFX8 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RFX8-associated genes across cancer lineages are OR6C68, PPBP, and IL22RA2. Each is linked with RFX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX8-to-partner and partner-to-RFX8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX8→partner) and Y-score (partner→RFX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6C68 →	+0.021	+5.415	.005	.004	3	1
LUNG_SCLC	PPBP →	+0.582	+3.736	<.001	.007	3	1
LUNG_SCLC	IL22RA2 →	+0.020	+3.523	<.001	.008	3	1
LUNG_SCLC	OR2D2 →	+0.041	+3.898	.008	.005	3	1
LUNG_SCLC	CD300C →	+0.244	+3.765	<.001	.006	3	1
LUNG_SCLC	ACTRT2 →	+0.008	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

RFX8 survival (RNA) · tumor vs normal (RNA) · all RFX8 data types