RFX7

Across TCGA patient cohorts, RFX7 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX7-associated genes across cancer lineages are TFRC, PCNA, and Notch1. Each is linked with RFX7 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX7-to-partner and partner-to-RFX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RFX7-low versus RFX7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX7→partner) and Y-score (partner→RFX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.658	+2.459	.013	.020	3	3
UCEC	PCNA →	+0.203	+1.750	<.001	<.001	3	3
COAD	Notch1 →	+0.235	+3.178	.010	.010	3	2
UCEC	Rictor_pT1135 →	-0.054	-1.247	.044	.041	3	2
UCEC	STAT3_pY705 →	-0.387	-2.273	<.001	<.001	3	2
UCEC	TIGAR →	+0.113	+1.455	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

TFRC by RFX7 expression — SKCM

Explore this box plot interactively →