RFX7

Across TCGA cell cohorts, RFX7 mutation is significantly associated with the RNA expression of many other genes, with 626 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX7-associated genes across cancer lineages are MTRNR2L10, FOXI2, and TMEM132C. Each is linked with RFX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX7-to-partner and partner-to-RFX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L10 grouped by RFX7-low versus RFX7-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX7→partner) and Y-score (partner→RFX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L10 →	+0.096	+4.209	.004	.006	3	2
LUNG_SCLC	FOXI2 →	+0.046	+4.058	<.001	.001	3	2
BLOOD_Leukemia	TMEM132C →	+0.550	+2.644	<.001	.008	3	2
SKIN	OR2F1 →	+0.005	+3.684	<.001	.006	3	2
LARGE_INTESTINE	LANCL1 →	+0.947	+3.212	.001	.006	3	2
LARGE_INTESTINE	WDR87 →	+0.018	+2.353	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 626 associations by consensus.

MTRNR2L10 by RFX7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →