Across TCGA patient cohorts, RFX6 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX6-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-7-cleavedD198, and GAPDH. Each is linked with RFX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX6-to-partner and partner-to-RFX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX6→partner) and Y-score (partner→RFX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.190	-1.794	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.506	+1.867	.004	.004	3	3
COAD	GAPDH →	+0.898	+3.008	<.001	.019	2	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.376	+2.415	.012	.002	3	2
UCEC	Tuberin →	+0.347	+2.247	<.001	.001	3	2
UCEC	MEK1 →	+0.494	+3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

RFX6 survival (RNA) · tumor vs normal (RNA) · all RFX6 data types