RFX5

Across TCGA patient cohorts, RFX5 mutation is significantly associated with the RNA expression of many other genes, with 2,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX5-associated genes across cancer lineages are GPHN, RAD51, and MCM5. Each is linked with RFX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX5-to-partner and partner-to-RFX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHN grouped by RFX5-low versus RFX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX5→partner) and Y-score (partner→RFX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPHN →	+0.403	+2.102	.006	.001	3	3
UCEC	RAD51 →	+0.983	+3.595	<.001	<.001	3	3
UCEC	MCM5 →	+0.493	+2.081	.004	.001	3	3
UCEC	OIP5 →	+0.900	+2.960	<.001	<.001	3	3
STAD	RN7SL544P →	+0.129	+5.187	<.001	.007	3	3
UCEC	TUBGCP5 →	+0.400	+2.102	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

GPHN by RFX5 expression — UCEC

Explore this box plot interactively →