RFX5

Across TCGA cell cohorts, RFX5 mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX5-associated genes across cancer lineages are PRR30, GALR1, and MAGEB10. Each is linked with RFX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX5-to-partner and partner-to-RFX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by RFX5-low versus RFX5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX5→partner) and Y-score (partner→RFX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRR30 →	+0.021	+4.269	<.001	.002	3	2
SKIN	GALR1 →	+0.972	+5.022	<.001	.002	3	1
SKIN	MAGEB10 →	+0.110	+4.095	<.001	.009	3	1
SKIN	PRAMEF17 →	+0.012	+5.022	<.001	.002	3	1
SKIN	PRAMEF33 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.334	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

PRR30 by RFX5 expression — BLOOD_Leukemia

Explore this box plot interactively →