RFX5-AS1

Across TCGA pan-cancer cohorts, RFX5-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RFX5-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RFX5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RFX5-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

ACC, LUAD, and OV are the cancer types where RFX5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.203	0.724	<.001	151	view →
LUAD	DFS	Tertile	All	0.487	0.181	<.001	61	view →
OV	OS	Median	All	0.362	0.281	.005	26	view →
CESC	OS	Median	III,IV	0.578	0.311	.032	18	view →
BRCA	DFS	Quartile	All	0.612	0.440	.001	15	view →
THYM	OS	Median	II,III,IV	1.000	0.888	.010	14	view →
LUSC	DFS	Tertile	All	0.883	0.712	.012	14	view →
ESCA	DFS	Tertile	IV	0.216	0.692	.024	13	view →
KIRC	DFS	Tertile	IV	0.243	0.499	.017	13	view →
HNSC	DFS	Quartile	IV	0.502	0.336	.024	10	view →
READ	OS	Median	II,III,IV	0.966	0.509	.011	8	view →
PAAD	DFS	Quartile	All	0.569	0.342	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RFX5-AS1–ACC (DFS)

Open the ACC breakdown →