RFX4

Across TCGA pan-cancer cohorts, RFX4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RFX4 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RFX4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RFX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

UCEC, SCLC, and SARC are the cancer types where RFX4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.933	0.430	.010	26	view →
SCLC	DFS	Median	II,III,IV	1.000	0.288	.009	11	view →
SARC	DFS	Median	All	0.115	0.613	.002	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
GBM	DFS	Median	All	0.048	0.242	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RFX4–UCEC (DFS)

Open the UCEC breakdown →