RFX4

Across TCGA patient cohorts, RFX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,106 significant associations in total. STAD shows the largest number of these associations.

The most reproducible RFX4-associated GO terms across cancer lineages are Response to UV, Obsolete regulation of histone modification, and Regulation of DNA-templated transcription elongation. Each is linked with RFX4 in more than 21 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to UV grouped by RFX4-low versus RFX4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Response to UV →	+0.064	+0.137	<.001	<.001	3	22
ESCA	Obsolete regulation of histone modification →	+0.066	+0.128	<.001	.001	3	21
STAD	Regulation of DNA-templated transcription elongation →	+0.069	+0.138	<.001	<.001	3	21
STAD	Regulation of transcription elongation by RNA polymerase II →	+0.069	+0.145	<.001	<.001	3	21
ESCA	Regulation of post-translational protein modification →	+0.086	+0.154	<.001	<.001	3	21
STAD	Positive regulation of DNA repair →	+0.060	+0.168	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,106 associations by consensus.

Response to UV by RFX4 expression — ESCA

Explore this box plot interactively →