RFX4

Across TCGA patient cohorts, RFX4 mutation is significantly associated with the RNA expression of many other genes, with 4,650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX4-associated genes across cancer lineages are ANKRD33B-AS1, AOC1, and EME1. Each is linked with RFX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD33B-AS1 grouped by RFX4-low versus RFX4-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	ANKRD33B-AS1 →	+0.140	+5.681	<.001	.001	3	3
UCEC	AOC1 →	-1.361	-2.321	.001	<.001	3	3
UCEC	EME1 →	+0.448	+2.290	.001	<.001	3	3
UCEC	ORC5 →	+0.334	+1.678	<.001	<.001	3	3
LUSC	METTL2B →	+0.404	+3.511	.002	.002	3	3
UCEC	ENTR1 →	+0.363	+2.413	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,650 associations by consensus.

ANKRD33B-AS1 by RFX4 expression — READ

Explore this box plot interactively →