RFX4

Across TCGA patient cohorts, RFX4 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX4-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and eEF2. Each is linked with RFX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RFX4-low versus RFX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.642	+2.273	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.162	+3.016	<.001	.018	3	3
UCEC	eEF2 →	+0.333	+2.415	.002	.002	3	3
UCEC	c-Kit →	-0.198	-1.754	.005	.001	3	3
LUAD	p70-S6K →	+0.241	+3.000	.039	.036	3	2
LUSC	ACC_pS79 →	+0.499	+3.468	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-B1 by RFX4 expression — UCEC

Explore this box plot interactively →