RFX4

Across TCGA cell cohorts, RFX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 793 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RFX4-associated GO terms across cancer lineages are Acute inflammatory response, Negative regulation of double-strand break repair via homologous recombination, and Nucleus localization. Each is linked with RFX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acute inflammatory response grouped by RFX4-low versus RFX4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Acute inflammatory response →	-0.148	-0.099	<.001	.001	3	4
LUNG_NSCLC_LUSC	Negative regulation of double-strand break repair via homologous recombination →	+0.074	+0.043	.001	.007	3	3
LUNG_NSCLC_LUSC	Nucleus localization →	+0.077	+0.044	<.001	.005	3	3
SOFT_TISSUE	Positive regulation of monoatomic ion transport →	-0.090	-0.169	<.001	.001	3	3
SOFT_TISSUE	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.103	+0.119	<.001	<.001	3	3
SOFT_TISSUE	Negative regulation of pinocytosis →	-0.339	-0.092	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

Acute inflammatory response by RFX4 expression — SOFT_TISSUE

Explore this box plot interactively →