RFX4

Across TCGA cell cohorts, RFX4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX4-associated genes across cancer lineages are SPATA31A5, ZIC3, and TMEM82. Each is linked with RFX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A5 grouped by RFX4-low versus RFX4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	ZIC3 →	+0.522	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TMEM82 →	+0.026	+5.643	<.001	.002	3	1
LARGE_INTESTINE	GUCY2F →	+0.010	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	TRIML1 →	+0.120	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SPATA31A5 by RFX4 expression — LUNG_SCLC

Explore this box plot interactively →