RFX4

Across TCGA cell cohorts, RFX4 mutation is significantly associated with the mutation status of many other genes, with 836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX4-associated genes across cancer lineages are CHSY3, F9, and UGGT2. Each is linked with RFX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX4-to-partner and partner-to-RFX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHSY3 grouped by RFX4-low versus RFX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX4→partner) and Y-score (partner→RFX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHSY3 →	+2.874	+3.632	.002	.002	1	3
LUNG_NSCLC_LUAD	F9 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	UGGT2 →	+5.339	+4.772	.004	.004	1	2
LUNG_NSCLC_LUAD	HHAT →	+4.339	+5.303	<.001	<.001	1	2
BLOOD_Lymphoma	XAF1 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	LONRF1 →	+4.429	+5.247	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

CHSY3 by RFX4 expression — LARGE_INTESTINE

Explore this box plot interactively →