RFX3-AS1

Across TCGA pan-cancer cohorts, RFX3-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RFX3-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RFX3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RFX3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRP show a favorable association.

BRCA, UVM, and KIRP are the cancer types where RFX3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	All	0.935	0.862	.001	57	view →
UVM	DFS	Quartile	III,IV	0.182	0.814	.001	57	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.276	.003	56	view →
SKCM	OS	Quartile	III,IV	0.569	0.207	<.001	35	view →
UCS	DFS	Median	IV	0.952	0.367	.001	34	view →
PAAD	DFS	Tertile	All	0.430	0.217	.003	21	view →
ACC	DFS	Median	IV	0.495	0.066	.001	20	view →
ESCA	DFS	Median	III,IV	0.456	0.241	.016	18	view →
OV	OS	Quartile	III,IV	0.877	0.756	.015	16	view →
LUAD	DFS	Median	IV	0.301	0.753	.006	13	view →
THCA	DFS	Median	III,IV	0.873	0.961	.018	13	view →
COAD	OS	Tertile	All	0.674	0.844	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RFX3-AS1–BRCA (DFS)

Open the BRCA breakdown →