RFX2

Across TCGA patient cohorts, RFX2 mutation is significantly associated with the RNA expression of many other genes, with 2,202 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX2-associated genes across cancer lineages are BUB3, NFASC, and KCNG1. Each is linked with RFX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RFX2-to-partner and partner-to-RFX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by RFX2-low versus RFX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX2→partner) and Y-score (partner→RFX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.440	+2.190	<.001	.008	3	4
UCEC	NFASC →	-0.409	-2.258	.007	.006	3	3
UCEC	KCNG1 →	-0.842	-1.652	.003	.006	3	3
UCEC	TIPIN →	+0.489	+1.960	<.001	<.001	3	3
COAD	HAUS2 →	+0.531	+3.199	.005	.009	3	3
UCEC	ADNP2 →	+0.549	+2.127	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,202 associations by consensus.

BUB3 by RFX2 expression — UCEC

Explore this box plot interactively →