RFX2

Across TCGA patient cohorts, RFX2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX2-associated genes across cancer lineages are ATM, PCNA, and TFRC. Each is linked with RFX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX2-to-partner and partner-to-RFX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RFX2-low versus RFX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX2→partner) and Y-score (partner→RFX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.685	-2.807	<.001	<.001	3	3
UCEC	PCNA →	+0.209	+2.321	.007	.001	3	3
UCEC	TFRC →	+0.503	+2.000	.008	.029	3	3
COAD	GAPDH →	+0.525	+2.820	.035	.035	3	2
UCEC	Cyclin-B1 →	+0.615	+2.321	.002	.001	3	2
UCEC	14-3-3_beta →	-0.087	-1.673	.016	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by RFX2 expression — UCEC

Explore this box plot interactively →