RFX2

Across TCGA cell cohorts, RFX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,240 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFX2-associated GO terms across cancer lineages are Regulation of protein localization to chromatin, mRNA transport, and Regulation of centriole-centriole cohesion. Each is linked with RFX2 in more than 12 cancer types. Because this analysis shows association rather than direction, both RFX2-to-partner and partner-to-RFX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to chromatin grouped by RFX2-low versus RFX2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX2→partner) and Y-score (partner→RFX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.148	+0.928	.001	.006	3	13
BONE	mRNA transport →	+0.092	+0.551	<.001	.001	3	13
PANCREAS	Regulation of centriole-centriole cohesion →	+0.101	+0.497	.001	.003	3	12
URINARY_TRACT	Mitotic G2 DNA damage checkpoint signaling →	+0.088	+0.952	.002	.001	3	12
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.106	+0.753	<.001	<.001	3	12
BONE	mRNA export from nucleus →	+0.103	+0.551	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,240 associations by consensus.

Regulation of protein localization to chromatin by RFX2 expression — LUNG_NSCLC_LUSC

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