RFX1

Across TCGA patient cohorts, RFX1 mutation is significantly associated with the RNA expression of many other genes, with 2,824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX1-associated genes across cancer lineages are RPSAP35, RN7SL743P, and RPS3AP1. Each is linked with RFX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP35 grouped by RFX1-low versus RFX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPSAP35 →	+0.057	+5.303	.001	.006	3	3
UCEC	RN7SL743P →	+0.136	+1.940	<.001	<.001	3	3
BLCA	RPS3AP1 →	+0.077	+4.433	<.001	.007	3	3
BRCA	MIR4726 →	+0.443	+4.382	<.001	.007	3	2
CESC	RNU6-644P →	+0.366	+4.193	.002	.009	3	2
CESC	UBE2V1P5 →	+0.119	+4.234	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,824 associations by consensus.

RPSAP35 by RFX1 expression — HNSC

Explore this box plot interactively →