RFX1

Across TCGA patient cohorts, RFX1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX1-associated genes across cancer lineages are GAPDH, p38-MAPK_pT180_Y182, and Caspase-7-cleavedD198. Each is linked with RFX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RFX1-low versus RFX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.480	+1.874	.014	.049	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.442	-2.321	.007	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.912	+1.847	<.001	.008	3	2
UCEC	c-Met_pY1235 →	+0.059	+2.232	.030	.005	3	2
SKCM	Tuberin_pT1462 →	+0.372	+3.321	.010	.010	3	1
SKCM	DJ-1 →	+0.257	+3.000	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

GAPDH by RFX1 expression — UCEC

Explore this box plot interactively →