RFX1

Across TCGA cell cohorts, RFX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,410 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFX1-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with RFX1 in more than 17 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by RFX1-low versus RFX1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of DNA-templated transcription initiation →	+0.227	+1.033	<.001	.001	3	18
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.227	+1.033	<.001	.001	3	18
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.158	+0.827	<.001	<.001	3	17
BONE	mRNA transport →	+0.113	+0.887	<.001	<.001	3	17
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.200	+1.099	<.001	<.001	3	17
BONE	mRNA alternative polyadenylation →	+0.097	+1.162	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,410 associations by consensus.

Negative regulation of DNA-templated transcription initiation by RFX1 expression — STOMACH

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