RFX1

Across TCGA cell cohorts, RFX1 mutation is significantly associated with the RNA expression of many other genes, with 855 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX1-associated genes across cancer lineages are CILK1, TRIM62, and SCD5. Each is linked with RFX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CILK1 grouped by RFX1-low versus RFX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CILK1 →	+0.721	+3.351	.001	.003	3	2
BLOOD_Leukemia	TRIM62 →	+0.715	+3.214	.001	.006	3	2
BLOOD_Leukemia	SCD5 →	+1.594	+3.351	.003	.003	3	2
BLOOD_Leukemia	RETREG1 →	+1.794	+3.351	<.001	.003	3	2
BLOOD_Leukemia	SGCB →	+1.864	+3.367	<.001	.002	3	2
BLOOD_Leukemia	KLKB1 →	+0.330	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

CILK1 by RFX1 expression — BLOOD_Leukemia

Explore this box plot interactively →