RFX1

Across TCGA cell cohorts, RFX1 mutation is significantly associated with the mutation status of many other genes, with 6,653 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX1-associated genes across cancer lineages are RELN, FBN1, and TBC1D17. Each is linked with RFX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RELN grouped by RFX1-low versus RFX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RELN →	+2.223	+2.892	<.001	<.001	1	5
OVARY	FBN1 →	+3.240	+4.467	.004	.004	1	4
CNS	TBC1D17 →	+5.614	+5.044	.003	.003	1	4
OVARY	PTPRS →	+3.240	+4.467	.004	.004	1	4
OVARY	PIK3CG →	+4.562	+5.217	<.001	<.001	1	4
OVARY	HIVEP2 →	+3.977	+4.930	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,653 associations by consensus.

RELN by RFX1 expression — BLOOD_Leukemia

Explore this box plot interactively →