RFWD3

Across TCGA pan-cancer cohorts, RFWD3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RFWD3 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RFWD3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RFWD3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and ESCA show a favorable association.

LUAD, UCEC, and ESCA are the cancer types where RFWD3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.057	0.680	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.829	.020	8	view →
ESCA	DFS	Median	III,IV	0.528	0.332	.027	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RFWD3–LUAD (OS)

Open the LUAD breakdown →