RFWD3

Across TCGA patient cohorts, RFWD3 mutation is significantly associated with the RNA expression of many other genes, with 864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFWD3-associated genes across cancer lineages are HSPD1P18, LINC01385, and PPIAP24. Each is linked with RFWD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFWD3-to-partner and partner-to-RFWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P18 grouped by RFWD3-low versus RFWD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFWD3→partner) and Y-score (partner→RFWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPD1P18 →	+0.276	+3.870	.002	.006	3	2
COAD	LINC01385 →	+0.183	+4.338	.003	.003	3	2
UCEC	PPIAP24 →	+0.110	+1.829	.002	.007	3	2
BLCA	SPATA31D3 →	+0.004	+4.229	<.001	.006	3	2
HNSC	GAGE2E →	+0.285	+5.023	<.001	.003	3	2
UCEC	RPL31P9 →	+0.133	+2.951	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 864 associations by consensus.

HSPD1P18 by RFWD3 expression — COAD

Explore this box plot interactively →