RFWD3

Across TCGA patient cohorts, RFWD3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFWD3-associated genes across cancer lineages are p62 Lck ligand, A-Raf_pS299, and ACVRL1. Each is linked with RFWD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFWD3-to-partner and partner-to-RFWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RFWD3-low versus RFWD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFWD3→partner) and Y-score (partner→RFWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.366	+3.469	.010	.002	3	2
UCEC	A-Raf_pS299 →	-0.170	-3.169	.001	.019	3	1
UCEC	ACVRL1 →	-0.120	-2.302	.044	.034	3	1
UCEC	JNK2 →	+0.242	+2.179	.005	.034	3	1
UCEC	MEK1 →	+0.368	+2.115	.021	.019	3	1
UCEC	MSH2 →	-0.339	-2.295	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p62 Lck ligand by RFWD3 expression — UCEC

Explore this box plot interactively →