RFWD3

Across TCGA cell cohorts, RFWD3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFWD3-associated genes across cancer lineages are LRRC3C, AVP, and ZAN. Each is linked with RFWD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFWD3-to-partner and partner-to-RFWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by RFWD3-low versus RFWD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFWD3→partner) and Y-score (partner→RFWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC3C →	+0.105	+3.796	<.001	.008	3	2
SOFT_TISSUE	AVP →	+0.097	+4.977	<.001	.002	3	1
SOFT_TISSUE	ZAN →	+0.004	+4.369	<.001	.008	3	1
SOFT_TISSUE	TEX44 →	+0.029	+4.417	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

LRRC3C by RFWD3 expression — BLOOD_Leukemia

Explore this box plot interactively →