RFTN2

Across TCGA patient cohorts, RFTN2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFTN2-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Gab2. Each is linked with RFTN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFTN2-to-partner and partner-to-RFTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RFTN2-low versus RFTN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFTN2→partner) and Y-score (partner→RFTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.632	+2.169	<.001	<.001	3	3
UCEC	FoxM1 →	+0.161	+1.415	.045	.010	3	2
UCEC	Gab2 →	+0.365	+1.847	<.001	.007	3	2
UCEC	mTOR_pS2448 →	-0.118	-2.209	.010	.009	3	2
UCEC	TFRC →	+0.389	+2.000	.018	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.418	+1.460	.023	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-B1 by RFTN2 expression — UCEC

Explore this box plot interactively →