RFTN2

Across TCGA cell cohorts, RFTN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,964 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFTN2-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Late viral transcription, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with RFTN2 in more than 10 cancer types. Because this analysis shows association rather than direction, both RFTN2-to-partner and partner-to-RFTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by RFTN2-low versus RFTN2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFTN2→partner) and Y-score (partner→RFTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of mRNA splicing, via spliceosome →	+0.075	+0.344	<.001	.006	3	11
BREAST	Late viral transcription →	+0.128	+0.181	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.116	+0.651	<.001	.004	3	10
LARGE_INTESTINE	mRNA splice site recognition →	+0.138	+0.179	<.001	.001	3	10
STOMACH	Regulation of RNA splicing →	+0.090	+0.274	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.136	+0.722	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,964 associations by consensus.

Regulation of mRNA splicing, via spliceosome by RFTN2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →