RFTN2

Across TCGA cell cohorts, RFTN2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFTN2-associated genes across cancer lineages are ARMH2, KRT71, and HES3. Each is linked with RFTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFTN2-to-partner and partner-to-RFTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMH2 grouped by RFTN2-low versus RFTN2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFTN2→partner) and Y-score (partner→RFTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARMH2 →	+0.040	+4.930	.001	.008	3	1
BLOOD_Lymphoma	KRT71 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	HES3 →	+0.133	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	SHOX →	+0.031	+4.523	<.001	.004	3	1
LARGE_INTESTINE	BRDT →	+0.122	+3.906	<.001	.002	3	1
LARGE_INTESTINE	CCDC195 →	+0.037	+3.297	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ARMH2 by RFTN2 expression — SOFT_TISSUE

Explore this box plot interactively →