Across TCGA pan-cancer cohorts, RFTN1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RFTN1P1’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RFTN1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types RFTN1P1 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.
LUAD and KIRC are the cancer types where RFTN1P1 tumor–normal differential expression is most reproducible.