RFT1

Across TCGA pan-cancer cohorts, RFT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RFT1 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RFT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RFT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where RFT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.503	0.923	.006	20	view →
PDAC	DFS	Median	III,IV	0.485	0.845	.011	14	view →
LSCC	DFS	Quartile	III,IV	1.000	0.339	.007	11	view →
GBM	DFS	Quartile	All	0.646	0.820	.005	8	view →
LUAD	OS	Quartile	III,IV	1.000	0.260	.010	7	view →
CCRCC	OS	Median	III,IV	0.662	0.907	.016	3	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RFT1–UCEC (DFS)

Open the UCEC breakdown →