RFT1

Across TCGA patient cohorts, RFT1 mutation is significantly associated with the RNA expression of many other genes, with 1,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFT1-associated genes across cancer lineages are RNU6-362P, LINC02876, and RPS29P32. Each is linked with RFT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFT1-to-partner and partner-to-RFT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-362P grouped by RFT1-low versus RFT1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFT1→partner) and Y-score (partner→RFT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-362P →	+0.690	+6.584	<.001	<.001	3	2
COAD	LINC02876 →	+0.085	+5.332	.003	.002	3	2
COAD	RPS29P32 →	+0.518	+4.666	<.001	.005	3	2
UCEC	VPS26C →	+0.464	+2.584	.001	.001	3	2
UCEC	NAE1 →	+0.485	+2.584	.004	.001	3	2
UCEC	TYW5 →	+0.303	+2.098	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,580 associations by consensus.

RNU6-362P by RFT1 expression — CESC

Explore this box plot interactively →