RFT1

Across TCGA patient cohorts, RFT1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFT1-associated genes across cancer lineages are VHL, eIF4E, and FoxM1. Each is linked with RFT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFT1-to-partner and partner-to-RFT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by RFT1-low versus RFT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFT1→partner) and Y-score (partner→RFT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.199	-2.700	<.001	.006	3	2
UCEC	eIF4E →	+0.184	+2.459	.034	.019	3	1
UCEC	FoxM1 →	+0.279	+2.321	.009	.006	3	1
UCEC	Ku80 →	+0.292	+2.472	.002	.010	3	1
UCEC	MEK1 →	+0.386	+3.584	.010	.002	3	1
UCEC	Notch1 →	+0.213	+1.807	<.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

VHL by RFT1 expression — UCEC

Explore this box plot interactively →