Across TCGA pan-cancer cohorts, RFPL4A RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RFPL4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RFPL4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFPL4A is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where RFPL4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFPL4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.078	.020	5	view →
KICH	All	All	−0.075	.012	4	view →
LUSC	Male	All	−0.061	.019	1	view →
COAD	Male	II,III,IV	−0.045	.029	1	view →
THCA	All	All	−0.043	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RFPL4A RNA expression & survival · all RFPL4A data types