RFPL3

Across TCGA patient cohorts, RFPL3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL3-associated genes across cancer lineages are MEK1, VHL, and Caspase-7-cleavedD198. Each is linked with RFPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFPL3-to-partner and partner-to-RFPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RFPL3-low versus RFPL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL3→partner) and Y-score (partner→RFPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.380	+2.906	.005	.001	3	2
UCEC	VHL →	-0.714	-1.807	.005	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.567	+2.242	.010	.005	3	2
UCEC	Di-Ras3 →	-0.110	-2.115	.047	.017	3	2
LUSC	p70-S6K_pT389 →	+0.248	+2.816	.003	.036	3	1
LUSC	PR →	+0.225	+2.816	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by RFPL3 expression — UCEC

Explore this box plot interactively →