RFPL2

Across TCGA patient cohorts, RFPL2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL2-associated genes across cancer lineages are FoxM1, STAT3_pY705, and 14-3-3_beta. Each is linked with RFPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFPL2-to-partner and partner-to-RFPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RFPL2-low versus RFPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL2→partner) and Y-score (partner→RFPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.219	+1.807	.040	.027	3	2
UCEC	STAT3_pY705 →	-0.370	-3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.115	-2.432	.005	.018	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.321	.007	.006	3	1
UCEC	GAPDH →	+0.557	+3.459	.011	.005	3	1
UCEC	Heregulin →	-0.156	-2.115	.002	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FoxM1 by RFPL2 expression — UCEC

Explore this box plot interactively →