RFPL2

Across TCGA cell cohorts, RFPL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,705 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RFPL2-associated GO terms across cancer lineages are Vacuolar acidification, Mitochondrial electron transport, ubiquinol to cytochrome c, and Endosomal lumen acidification. Each is linked with RFPL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both RFPL2-to-partner and partner-to-RFPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar acidification grouped by RFPL2-low versus RFPL2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL2→partner) and Y-score (partner→RFPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Vacuolar acidification →	+0.066	+0.373	.002	.003	3	7
BLOOD_Leukemia	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.065	+0.079	<.001	.001	3	7
SKIN	Endosomal lumen acidification →	+0.117	+0.591	<.001	.002	3	6
KIDNEY	Intracellular pH reduction →	+0.063	+0.373	.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Cardiac muscle cell action potential →	-0.189	-0.167	<.001	.004	3	6
LARGE_INTESTINE	Embryonic organ development →	-0.027	-0.127	.004	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,705 associations by consensus.

Vacuolar acidification by RFPL2 expression — KIDNEY

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