Across TCGA patient cohorts, RFLNB protein abundance is significantly associated with the RNA expression of many other genes, with 13,845 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RFLNB-associated genes across cancer lineages are HLX, ITGA5, and LOXL2. Each is linked with RFLNB in more than 6 cancer types. Because this analysis shows association rather than direction, both RFLNB-to-partner and partner-to-RFLNB results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNB→partner) and Y-score (partner→RFLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HLX →	+0.469	+0.347	.004	.005	3	7
OV	ITGA5 →	+1.152	+0.467	.001	<.001	3	7
PDAC	LOXL2 →	+0.767	+0.358	<.001	.001	3	7
OV	COL1A1 →	+1.949	+0.413	<.001	<.001	3	6
OV	LAMA4 →	+1.215	+0.562	.004	.001	3	6
GBM	CD93 →	+0.926	+0.453	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,845 associations by consensus.

Exploration

RFLNB survival (RNA) · tumor vs normal (RNA) · all RFLNB data types