Across TCGA patient cohorts, RFLNB mutation is significantly associated with the RNA expression of many other genes, with 1,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFLNB-associated genes across cancer lineages are RNA5SP499, PDLIM1P1, and SAP30-DT. Each is linked with RFLNB in more than 1 cancer types. Because this analysis shows association rather than direction, both RFLNB-to-partner and partner-to-RFLNB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNB→partner) and Y-score (partner→RFLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP499 →	+0.083	+3.668	<.001	.009	3	2
UCEC	PDLIM1P1 →	+0.342	+4.040	<.001	<.001	3	1
UCEC	SAP30-DT →	+0.319	+3.502	.008	.002	3	1
UCEC	CHASERR →	+0.584	+2.040	.001	.005	3	1
UCEC	CWC25 →	+0.366	+3.016	.005	<.001	3	1
UCEC	TAF9 →	+0.542	+2.721	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,249 associations by consensus.

Exploration

RFLNB survival (RNA) · tumor vs normal (RNA) · all RFLNB data types