Across TCGA patient cohorts, RFLNB mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFLNB-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with RFLNB in more than 1 cancer types. Because this analysis shows association rather than direction, both RFLNB-to-partner and partner-to-RFLNB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNB→partner) and Y-score (partner→RFLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.308	.001	.006	3	1
UCEC	EGFR_pY1068 →	-0.296	-3.459	.004	.005	3	1
UCEC	A-Raf_pS299 →	-0.169	-3.459	<.001	.005	3	1
UCEC	Fibronectin →	-0.306	-2.321	.024	.006	3	1
UCEC	MEK1 →	+0.314	+2.321	.037	.006	3	1
UCEC	p62 Lck ligand →	+0.398	+3.469	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

RFLNB survival (RNA) · tumor vs normal (RNA) · all RFLNB data types