Across TCGA cell cohorts, RFLNB mutation is significantly associated with the mutation status of many other genes, with 1,387 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFLNB-associated genes across cancer lineages are ASMTL, TADA3, and SHISA6. Each is linked with RFLNB in more than 2 cancer types. Because this analysis shows association rather than direction, both RFLNB-to-partner and partner-to-RFLNB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNB→partner) and Y-score (partner→RFLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASMTL →	+3.479	+4.932	.002	.002	1	3
SKIN	TADA3 →	+4.392	+5.357	<.001	<.001	1	3
SKIN	SHISA6 →	+4.392	+4.392	.009	.009	1	3
BLOOD_Leukemia	RTN1 →	+4.309	+4.560	.007	.007	1	3
SKIN	UACA →	+4.392	+4.392	.009	.009	1	2
SKIN	COPS3 →	+5.977	+5.977	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,387 associations by consensus.

Exploration

RFLNB survival (RNA) · tumor vs normal (RNA) · all RFLNB data types