RFFL

Across TCGA pan-cancer cohorts, RFFL Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RFFL data layer compared with 29 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RFFL Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RFFL expression acts as an unfavorable survival marker.

SKCM, LUAD, and CESC are the cancer types where RFFL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.135	0.761	<.001	14	view →
LUAD	OS	Median	All	0.348	0.688	.005	8	view →
CESC	OS	Median	All	0.089	0.585	.025	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RFFL–SKCM (DFS)

Open the SKCM breakdown →