RFFL

Across TCGA pan-cancer cohorts, RFFL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RFFL data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RFFL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RFFL expression acts as an unfavorable survival marker.

LUAD, GBM, and PDAC are the cancer types where RFFL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.632	0.870	.001	35	view →
GBM	DFS	Tertile	All	0.260	0.446	.003	20	view →
PDAC	DFS	Quartile	All	0.349	0.688	.038	4	view →
CCRCC	DFS	Median	All	0.639	0.893	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RFFL–LUAD (OS)

Open the LUAD breakdown →