RFFL

Across TCGA pan-cancer cohorts, RFFL mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RFFL’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where RFFL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RFFL is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

LSCC, HNSC, and PDAC are the cancer types where RFFL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFFL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.430	<.001	9	view →
HNSC	All	IV	−0.366	.002	8	view →
PDAC	Female	All	+0.910	.001	5	view →
LUAD	Male	All	−0.187	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RFFL–LSCC

Open the LSCC breakdown →