RFFL

Across TCGA patient cohorts, RFFL protein abundance is significantly associated with the RNA expression of many other genes, with 9,943 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RFFL-associated genes across cancer lineages are OSGIN1, LINC02561, and TCIRG1. Each is linked with RFFL in more than 2 cancer types. Because this analysis shows association rather than direction, both RFFL-to-partner and partner-to-RFFL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RFFL versus OSGIN1 in LSCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFFL→partner) and Y-score (partner→RFFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	OSGIN1 →	+1.751	+0.339	<.001	<.001	3	3
LSCC	LINC02561 →	+1.557	+0.211	.002	.006	3	3
OV	TCIRG1 →	+1.311	+0.490	.001	.004	3	2
OV	GORASP2 →	-0.562	-0.565	<.001	.001	3	2
OV	MIS18A →	-1.187	-0.625	.001	.008	3	2
OV	BICDL2 →	+1.080	+0.686	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,943 associations by consensus.

RFFL vs OSGIN1 — LSCC

Explore this scatter interactively →