RFFL

Across TCGA patient cohorts, RFFL mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFFL-associated genes across cancer lineages are lymphatic Endothelial cells, Mesangial cells, and CD4+ Tem. Each is linked with RFFL in more than 1 cancer types. Because this analysis shows association rather than direction, both RFFL-to-partner and partner-to-RFFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, lymphatic Endothelial cells grouped by RFFL-low versus RFFL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFFL→partner) and Y-score (partner→RFFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	lymphatic Endothelial cells →	-0.025	-3.290	.013	.010	3	1
UCEC	Mesangial cells →	-0.040	-2.983	.015	.036	3	1
CESC	CD4+ Tem →	+0.002	+7.174	<.001	.013	3	1
UCEC	Astrocytes →	-0.041	-2.229	.034	.022	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

lymphatic Endothelial cells by RFFL expression — UCEC

Explore this box plot interactively →