RFFL

Across TCGA cell cohorts, RFFL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,321 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFFL-associated GO terms across cancer lineages are Cellular response to thyroid hormone stimulus, Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, and Receptor recycling. Each is linked with RFFL in more than 8 cancer types. Because this analysis shows association rather than direction, both RFFL-to-partner and partner-to-RFFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to thyroid hormone stimulus grouped by RFFL-low versus RFFL-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFFL→partner) and Y-score (partner→RFFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Cellular response to thyroid hormone stimulus →	+0.189	+1.094	<.001	.001	3	9
BLOOD_Lymphoma	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.152	+1.653	<.001	<.001	3	9
KIDNEY	Receptor recycling →	+0.067	+0.882	<.001	.001	3	9
BONE	Regulation of endothelial cell development →	+0.127	+0.644	.003	<.001	3	8
BONE	Regulation of establishment of endothelial barrier →	+0.127	+0.644	.003	<.001	3	8
BONE	Negative regulation of epidermal growth factor receptor signaling pathway →	+0.121	+0.975	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Cellular response to thyroid hormone stimulus by RFFL expression — KIDNEY

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