RFFL

Across TCGA cell cohorts, RFFL mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFFL-associated genes across cancer lineages are R3HDML, HTR3D, and GDF5-AS1. Each is linked with RFFL in more than 1 cancer types. Because this analysis shows association rather than direction, both RFFL-to-partner and partner-to-RFFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by RFFL-low versus RFFL-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFFL→partner) and Y-score (partner→RFFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	GDF5-AS1 →	+0.014	+2.657	.002	.007	3	1
BLOOD_Leukemia	CLPS →	+0.073	+5.539	<.001	.003	3	1
LARGE_INTESTINE	CHRNA2 →	+0.071	+2.716	<.001	.009	2	1
LARGE_INTESTINE	HTR3A →	+0.525	+3.392	.004	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

R3HDML by RFFL expression — BLOOD_Lymphoma

Explore this box plot interactively →