RFC5

Across TCGA pan-cancer cohorts, RFC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RFC5 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RFC5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where RFC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	35	view →
CCRCC	OS	Tertile	All	0.874	1.000	.008	28	view →
LUAD	DFS	Tertile	II,III,IV	0.987	0.646	.013	11	view →
PDAC	OS	Tertile	II,III,IV	0.414	0.631	.007	8	view →
LSCC	DFS	Tertile	II,III,IV	0.846	0.468	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RFC5–HNSC (OS)

Open the HNSC breakdown →